Bioactive Small Molecules
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Filtered Search Results
Cayman Chemical Reuterin, Purity: ≥95%, CAS: 2134-29-4, 100 mg
A bacterial glycerol metabolite with antibacterial activity; is produced by L. reuteri during exposure to live or UV-killed E. coli; active against E. coli and several species of Bacteroides, Bifidobacterium, and Eubacterium (MICs = 1.9-15 mM) as well as C. difficile and B. vulgatus (MICs = C. difficile at 2.5 mM; alters the bacterial composition of, and VOCs produced by, the mouse fecal microbiome
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Cayman Chemical Xanthine, Purity: ≥98%, CAS: 69-89-6, 10 g
A purine base and intermediate in uric acid biosynthesis; been found in a variety of commercial foodstuffs; urinary levels are decreased in patients with primary gout; has been used in the synthesis of xanthine derivatives that have anticancer or anti-inflammatory activities in vitro
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Cayman Chemical 5-hydroxy Diclofenac, Purity: ≥95%, CAS: 69002-84-2, 5 mg
An active metabolite of diclofenac; cytotoxic to HL-60 leukemia cells (IC50 = 661 µM); induces apoptosis and increases caspase-3 activity in rat hepatocytes in a concentration-dependent manner
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TARGETMOL CHEMICALS INC K777 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. K777 is a potent orally active and irreversible inhibitor of cysteine protease. K777 is a potent CYP3A4 inhibitor (IC50= 60 nM). K777 is also a selective CCR4 antagonist featuring the potent chemotaxis inhibition. K777 irreversibly inhibits Cruzain which is the major cysteine protease of Trypansoma cruzi and cathepsins B and L. K777 targets cathepsin-mediated cell entry and wxibits a broad-spectrum antiviral activity. K777 inhibits EBOV and SARS-CoV pseudovirus entry with IC50 values of 0.87 nM and 0.68 nM respectively. purity: 99%
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Selleck Chemical LLC Bestatin hydrochloride E4916-5MG
Bestatin hydrochloride is an inhibitor of aminopeptidase N and enkephalinase that elevates the levels of angiotensin II and angiotensin III It also acts as a non-competitive inhibitor ( 1) of porcine DPP-IV with a Ki value of 75 M It reduces DPP-IV activity decreases cell viability and increases DNA fragmentation in vitro It has the potential to treat skin conditions like acne psoriasis and keloids
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Medchemexpress LLC CLEC12A/MICL Cynomo 50ug | 50ug
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CLEC12A/MICL Protein is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily CLEC12A is a cell surface receptor known to regulate signaling cascades and facilitate the tyrosine phosphorylation of target MAP kinases It interacts with PTPN6 and PTPN11 indicating its involvement in intricate cellular signaling processes CLEC12A/MICL Protein Cynomolgus (HEK293 His) is the recombinant cynomolgus-derived CLEC12A/MICL protein expressed by HEK293 with N-His labeled tag
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AdipoGen Hydroxyectoine
Natural chemical product. CAS 165542-15-4. Formula C6H10N2O3. MW 158.2. Isolated from halophilic bacteria Halomonas elongata. The ectoines belong to the class of compatible solutes also called extremolytes osmolytes from extremophiles. Extremolytes stabilize biological structures and macromolecules such as lipid membranes and proteins against a variety of stress factors, including high temperature, freeze-thaw cycles, drying and degradation. These very stable, non-toxic, animal-free protective agents are powerful additives in various Life Science applications, ranging from cryoprotection of animal cells over protein storage to PCR. They are protective osmolytes selected by nature for stabilization of all proteins in the cell against denaturing environmental stress without altering their functional activity. The stabilizing effect is based on the fact, that the protective osmolytes are strong water-structure formers and as such are preferentially excluded from the protein surface.
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TARGETMOL CHEMICALS INC AZD-4877 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. AZD-4877 is a potent spindle kinesin (Eg5) inhibitor with an IC50 value of 2 nM. AZD-4877 is an alternative configuration of Ispinesib that inhibits mitosis induces the formation of a unipolar spindle phenotype and mediates apoptosis. AZD-4877 has antitumor activity and inhibits circulating peripheral blood mononuclear cells (PBMC). purity: 99%
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Cayman Chemical 16-methyl Stearic Acid, Purity: ≥90%, CAS: 17001-28-4, 5 mg
A methyl branched-chain fatty acid
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Cayman Chemical Imazalil-d5 (sulfate), Purity: ≥99% deuterated forms (d1-d5), CAS: 1398065-92-3, 5 mg
An internal standard for the quantification of imazalil by GC- or LC-MS
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Cayman Chemical JG-98, Purity: ≥98%, CAS: 1456551-16-8, 1 mg
An inhibitor of the Hsp70-BAG-3 protein-protein interaction (IC50 = 1.6 µM); reduces the proliferation of MDA-MB-231 and MCF-7 cells (EC50s = 0.4 and 0.7 µM, respectively) and 22 other cancer cell lines (EC50s = 0.3-4 µM); toxic to MEFs (EC50 = 22 µM); reduces tumor growth in MCF-7 breast cancer and HeLa cervical cancer mouse xenograft models at 3 mg/kg every two days
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Cayman Chemical 1-Palmitoyl-2-11(Z)-Octadecenoyl-3-Butyroyl-rac-glycerol, Purity: ≥98%, CAS: 2692623-15-5, 5 mg
A triacylglycerol
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Apexbio Technology LLC BMS-927711(Synonyms: Rimegepant, Nurtec ODT, BMS927711, BMS 927711, BHV-3000, BHV3000), 25mg, CAS: 1289023-67-1.
BMS-927711 (CAS 1289023-67-1) is an orally bioavailable antagonist targeting the calcitonin gene-related peptide (CGRP) receptor CGRP acts through a G-protein coupled receptor composed of calcitonin receptor-like receptor (CLR) receptor activity-modifying protein 1 (RAMP1) and receptor component protein (RCP) Research shows that CGRP levels are elevated during migraine episodes suggesting a role in migraine pathogenesis In binding assays using SK-N-MC cell membranes expressing endogenous human CGRP receptors BMS-927711 exhibited potent CGRP receptor antagonism (IC50 0 14 nM) Clinical studies have demonstrated its potential application in the acute treatment of migraine
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Medchemexpress LLC Cathepsin L1 Human 10ug | 10ug
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Cathepsin L1 protein is a thiol protease that plays a key role in lysosomal protein degradation affecting cellular functions such as turnover antigen processing and bone remodeling It dissolves cross-linked TG/thyroglobulin releasing the thyroid hormone thyroxine (T4) in the thyroid follicular cavity Cathepsin L1 Protein Human (HEK293 C-His) is the recombinant human-derived Cathepsin L1 protein expressed by HEK293 with C-6 His labeled tag
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![AdipoGen VR23 [Proteasome Inhibitor] (5 mg)](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502054067.PNG-250.jpg)
AdipoGen VR23 [Proteasome Inhibitor] (5 mg)
Chemical. CAS: 1624602-30-7. Formula: C19H16ClN5O6S. MW: 477.9. Synthetic. Potent selective and reversible chloroquine derivative 20S proteasome inhibitor (all proteolytic subunits). Targets the trypsin-like beta2 subunit of the constitutive 20S proteasome (IC50=1nM). Cross-reacts and inhibits the chymotrypsin-like beta5 subunit (IC50=50-100nM) and the caspase-like/peptidyl-glutamyl peptide-hydrolyzing (PGPH) beta1 subunit (IC50=3µM). Anticancer compound effective in cell-based assays and against multiple myeloma and metastatic breast cancer in vivo. In vitro, induces cell cycle arrest and apoptosis in human cancer cell lines including multiple myeloma, as well as in bortezomib-resistent multiple myeloma cells, but with minimal effects on non-cancerous cells.
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